You can benefit from using MFC and C run-time portability features even if you do not currently intend to internationalize your application:
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Coding portably makes your code base flexible. You can later move it easily to Unicode or MBCS.
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Using Unicode makes your applications for Windows 2000 more efficient. Because Windows 2000 uses Unicode, non-Unicode strings passed to and from the operating system must be translated, which incurs overhead.
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Using MBCS enables you to support international markets on Win32 platforms other than Windows 2000, such as Windows 95 or Windows 98.